Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges

Sun, Guoqiang; Rong, Dawei; Li, Zhouxiao; Sun, Guangshun; Wu, Fan; Li, Xiao; Cao, Hongyong; Cheng, Ye; Tang, Weiwei und Sun, Yangbai (8. September 2021): Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges. In: Frontiers in Cell and Developmental Biology, Bd. 9, 694363

Abstract

Research on molecular targeted therapy of tumors is booming, and novel targeted therapy drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy drugs, can be administered orally as tablets among other methods, and do not draw upon genes, causing no immune response. It is easily structurally modified to make it more applicable to clinical needs, and convenient to promote due to low cost. It refers to a hotspot in the research of tumor molecular targeted therapy. In the present study, we review the current Food and Drug Administration (FDA)-approved use of small molecule targeted compounds in tumors, summarize the clinical drug resistance problems and mechanisms facing the use of small molecule targeted compounds, and predict the future directions of the evolving field.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Small molecular compounds; carcinoma; drug resistance; target; therapy
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2296-634X
• Sprache: Englisch