Abstract
Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG latencies, and improved locomotor recovery. Functional recovery after spinal cord injury is guided by the formation of new spinal detour circuits. The authors show that the formation of these circuits is enhanced by targeted chemogenetic stimulation of supraspinal and spinal neuron populations. Supraspinal and spinal coordinated stimulation potentiated behavioral recovery.
Item Type: | Journal article |
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Faculties: | Medicine Medicine > Munich Cluster for Systems Neurology (SyNergy) |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-115218-5 |
ISSN: | 0022-1007 |
Language: | English |
Item ID: | 115218 |
Date Deposited: | 02. Apr 2024, 08:11 |
Last Modified: | 07. Jun 2024, 11:43 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 118803580 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 408885537 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |