ORCID: https://orcid.org/0000-0002-2471-5807; Müller-Reif, Johannes B. ORCID: https://orcid.org/0000-0003-3454-2396; Zhang, Zhe ORCID: https://orcid.org/0000-0002-1163-7897; Ehreiser, Vincent ORCID: https://orcid.org/0000-0002-8820-8839; Huth, Judith; Shchurovska, Khrystyna; Kilani, Badr ORCID: https://orcid.org/0000-0003-0230-094X; Schweizer, Lisa ORCID: https://orcid.org/0000-0002-1165-7804; Geyer, Philipp E. ORCID: https://orcid.org/0000-0001-7980-4826; Zwiebel, Maximilian ORCID: https://orcid.org/0000-0002-7005-5619; Novotny, Julia ORCID: https://orcid.org/0000-0002-0929-0273; Lüsebrink, Enzo ORCID: https://orcid.org/0000-0002-3214-5672; Little, Gemma ORCID: https://orcid.org/0000-0001-9810-4358; Orban, Martin ORCID: https://orcid.org/0000-0001-9830-1941; Nicolai, Leo ORCID: https://orcid.org/0000-0003-0776-5885; El Nemr, Shaza ORCID: https://orcid.org/0000-0003-4542-693X; Titova, Anna ORCID: https://orcid.org/0009-0005-7412-7447; Spannagl, Michael; Kindberg, Jonas ORCID: https://orcid.org/0000-0003-1445-4524; Evans, Alina L. ORCID: https://orcid.org/0000-0003-0513-4887; Mach, Orpheus ORCID: https://orcid.org/0000-0002-7092-7050; Vogel, Matthias ORCID: https://orcid.org/0009-0002-1563-4519; Tiedt, Steffen ORCID: https://orcid.org/0000-0002-8817-8457; Ormanns, Steffen ORCID: https://orcid.org/0000-0002-0754-9034; Kessler, Barbara; Dueck, Anne ORCID: https://orcid.org/0000-0002-7956-6327; Friebe, Andrea; Jørgensen, Peter Godsk ORCID: https://orcid.org/0000-0002-1217-8944; Majzoub-Altweck, Monir; Blutke, Andreas; Polzin, Amin ORCID: https://orcid.org/0000-0002-5891-9672; Stark, Konstantin; Kääb, Stefan ORCID: https://orcid.org/0000-0001-8824-3581; Maier, Doris ORCID: https://orcid.org/0000-0002-3261-2381; Gibbins, Jonathan M.; Limper, Ulrich ORCID: https://orcid.org/0000-0001-9927-4180; Frobert, Ole ORCID: https://orcid.org/0000-0002-5846-345X; Mann, Matthias ORCID: https://orcid.org/0000-0003-1292-4799; Massberg, Steffen ORCID: https://orcid.org/0000-0001-7387-3986 und Petzold, Tobias ORCID: https://orcid.org/0000-0001-7805-5632
(2023):
Immobility-associated thromboprotection is conserved across mammalian species from bear to human.
In: Science, Bd. 380, Nr. 6641: S. 178-187
Abstract
When humans experience acute immobility caused by illness or injury, they are at increased risk for potentially deadly venous thromboembolism. By contrast, hibernating bears remain immobile for months every year without experiencing any such complications. Similarly, chronically immobilized patients with spinal cord injury do not have an increased risk of thrombosis. By examining blood from humans experiencing chronic immobilization, healthy volunteers on extended bed rest, and free-ranging brown bears during their periods of activity and hibernation, Thienel et al. identified specific proteins that are down-regulated during periods of prolonged immobility and protect from thrombosis (see the Perspective by Schattner)
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| EU Funded Grant Agreement Number: | 833440 |
| EU-Projekte: | Horizon 2020 > ERC Grants > ERC Advanced Grant > ERC Grant 833440: IMMUNOTHROMBOSIS - Cross-talk between platelets and immunity - implications for host homeostasis and defense |
| Fakultät: | Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik I (Kardiologie) |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 0036-8075 |
| Sprache: | Englisch |
| Dokumenten ID: | 116842 |
| Datum der Veröffentlichung auf Open Access LMU: | 03. Jun. 2024, 13:19 |
| Letzte Änderungen: | 03. Jun. 2024, 13:19 |
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