RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells

Andreas, Nico; Potthast, Maria; Geiselhoeringer, Anna-Lena; Garg, Garima; de Jong, Renske; Riewaldt, Julia; Russkamp, Dennis; Riemann, Marc; Girard, Jean-Philippe; Blank, Simon; Kretschmer, Karsten; Schmidt-Weber, Carsten; Korn, Thomas; Weih, Falk und Ohnmacht, Caspar (2019): RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. In: Journal of Immunology, Bd. 203, Nr. 10: S. 2602-2613

Abstract

Foxp(3+) regulatory T cells are well-known immune suppressor cells in various settings. In this study, we provide evidence that knockout of the relB gene in dendritic cells (DCs) of C57BL/6 mice results in a spontaneous and systemic accumulation of Foxp(3+) T regulatory T cells (Tregs) partially at the expense of microbiota-reactive Tregs. Deletion of nfkb2 does not fully recapitulate this phenotype, indicating that alternative NF-kappa B activation via the RelB/p52 complex is not solely responsible for Treg accumulation. Deletion of Re1B in DCs further results in an impaired oral tolerance induction and a marked type 2 immune bias among accumulated Foxp(3+) Tregs reminiscent of a tissue Treg signature. Tissue Tregs were fully functional, expanded independently of IL-33, and led to an almost complete Treg-dependent protection from experimental autoimmune encephalomyelitis. Thus, we provide clear evidence that RelB-dependent pathways regulate the capacity of DCs to quantitatively and qualitatively impact on Treg biology and constitute an attractive target for treatment of autoimmune diseases but may come at risk for reduced immune tolerance in the intestinal tract.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198