Involvement of the Macrophage Migration Inhibitory Factor (MIF) in Lipedema

Vasella, Mauro; Wolf, Stefan; Francis, Eamon C.; Grieb, Gerrit; Pfister, Pablo; Reid, Gregory; Bernhagen, Juergen; Lindenblatt, Nicole; Gousopoulos, Epameinondas und Kim, Bong-Sung (2023): Involvement of the Macrophage Migration Inhibitory Factor (MIF) in Lipedema. In: Metabolites, Bd. 13, Nr. 10, 1105

Abstract

Lipedema is a chronic disorder that mainly affects women. It is often misdiagnosed, and its etiology remains unknown. Recent research indicates an accumulation of macrophages and a shift in macrophage polarization in lipedema. One known protein superfamily that contributes to macrophage accumulation and polarization is the macrophage migration inhibitory factor (MIF) family. MIF-1 and MIF-2 are ubiquitously expressed and also regulate inflammatory processes in adipose tissue. In this study, the expression of MIF-1, MIF-2 and CD74-a common receptor for both cytokines-was analyzed in tissue samples of 11 lipedema and 11 BMI-matched, age-matched and anatomically matched control patients using qPCR and immunohistochemistry (IHC). The mRNA expression of MIF-1 (mean 1.256;SD 0.303;p = 0.0485) and CD74 (mean 1.514;SD 0.397;p = 0.0097) were significantly elevated in lipedema patients, while MIF-2 expression was unaffected (mean 1.004;SD 0.358;p = 0.9718). The IHC analysis corroborated the results for CD74 expression on a cellular level. In conclusion, our results provide first evidence for a potential involvement of the MIF family, presumably via the MIF-1-CD74 axis, in lipedema.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198