FG-nucleoporins caught in the act of liquid-liquid phase separation

Dormann, Dorothee (2020): FG-nucleoporins caught in the act of liquid-liquid phase separation. In: Journal of Cell Biology, Bd. 219, Nr. 1, e201910211

Abstract

The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid-liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198