Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

Xiao, Yan; Hoodless, Laura J.; Petrucco, Luigi; Portugues, Ruben and Czopka, Tim (2022): Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. In: Nature Neuroscience, Vol. 25, No. 3: 280-+

Abstract

Oligodendrocyte precursor cells exist in abundance throughout the brain lifelong, with unclear functions. Xiao et al. show that, in zebrafish, these cells regulate the precise formation of retinal ganglion cell arbors and fine-tune visual processing. Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.

• Item Type: Journal article
• Faculties: Medicine > Munich Cluster for Systems Neurology (SyNergy)
• Subjects: 600 Technology > 610 Medicine and health
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198