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Kapurniotu, Aphrodite und Bernhagen, Jurgen (2023): Lasso-grafted designer cytokines. In: Nature Biomedical Engineering, Bd. 7, Nr. 2: S. 89-91 [PDF, 1MB]

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Abstract

Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood-brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.

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