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Brandhofer, Markus und Bernhagen, Juergen (2022): Cytokine aerobics: Oxidation controls cytokine dynamics and function. In: Structure, Bd. 30, Nr. 6: S. 787-790 [PDF, 586kB]

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Abstract

In this issue of Structure, Skeens et al. provide insights into the structure and dynamics of an oxidized form of the atypical cytokine macrophage migration-inhibitory factor (MIF). The study unveils a surprising conformational susceptibility of MIF to ambient redox alterations and identifies redox-sensitive residues and latent allostery sites with functional relevance.

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