Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex

Mezydlo, Aleksandra; Treiber, Nils; Gavilanes, Emily Melisa Ullrich; Eichenseer, Katharina; Ancau, Mihai; Wens, Adinda; Carral, Carla Ares; Schifferer, Martina; Snaidero, Nicolas; Misgeld, Thomas und Kerschensteiner, Martin (2023): Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex. In: Neuron, Bd. 111, Nr. 11: S. 1748-1769

Abstract

In multiple sclerosis, an inflammatory attack results in myelin loss, which can be partially reversed by remye-lination. Recent studies suggest that mature oligodendrocytes could contribute to remyelination by gener-ating new myelin. Here, we show that in a mouse model of cortical multiple sclerosis pathology, surviving ol-igodendrocytes can indeed extend new proximal processes but rarely generate new myelin internodes. Furthermore, drugs that boost myelin recovery by targeting oligodendrocyte precursor cells did not enhance this alternate mode of myelin regeneration. These data indicate that the contribution of surviving oligoden-drocytes to myelin recovery in the inflamed mammalian CNS is minor and inhibited by distinct remyelination brakes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198