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Haass, Christian und Willem, Michael (2019): Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention? In: Neuron, Bd. 101, Nr. 4: S. 557-559

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Abstract

The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-beta peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABA(B)R1a.

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