Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer's disease-A systematic model evaluation

Nemali, A.; Vockert, N.; Berron, D.; Maas, A.; Bernal, J.; Yakupov, R.; Peters, O.; Gref, D.; Cosma, N.; Preis, L.; Priller, J.; Spruth, E.; Altenstein, S.; Lohse, A.; Fliessbach, K.; Kimmich, O.; Vogt, I.; Wiltfang, J.; Hansen, N.; Bartels, C.; Schott, B. H.; Maier, F.; Meiberth, D.; Glanz, W.; Incesoy, E.; Butryn, M.; Buerger, K.; Janowitz, D.; Pernecky, R.; Rauchmann, B.; Burow, L.; Teipel, S.; Kilimann, I.; Goeerss, D.; Dyrba, M.; Laske, C.; Munk, M.; Sanzenbacher, C.; Mueller, S.; Spottke, A.; Roy, N.; Heneka, M.; Brosseron, F.; Roeske, S.; Dobisch, L.; Ramirez, A.; Ewers, M.; Dechent, P.; Scheffler, K.; Kleineidam, L.; Wolfsgruber, S.; Wagner, M.; Jessen, F.; Duzel, E. und Ziegler, G. (2023): Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer's disease-A systematic model evaluation. In: Medical Image Analysis, Bd. 90, 102913

Abstract

Neuroimaging markers based on Magnetic Resonance Imaging (MRI) combined with various other measures (such as genetic covariates, biomarkers, vascular risk factors, neuropsychological tests etc.) might provide useful predictions of clinical outcomes during the progression towards Alzheimer's disease (AD). The use of multiple features in predictive frameworks for clinical outcomes has become increasingly prevalent in AD research. However, many studies do not focus on systematically and accurately evaluating combinations of multiple input features. Hence, the aim of the present work is to explore and assess optimal combinations of various features for MR-based prediction of (1) cognitive status and (2) biomarker positivity with a multi kernel learning Gaussian process framework. The explored features and parameters included (A) combinations of brain tissues, modulation, smoothing, and image resolution;(B) incorporating demographics & clinical covariates;(C) the impact of the size of the training data set;(D) the influence of dimensionality reduction and the choice of kernel types. The approach was tested in a large German cohort including 959 subjects from the multicentric longitudinal study of cognitive impairment and dementia (DELCODE). Our evaluation suggests the best prediction of memory performance was obtained for a combination of neuroimaging markers, demographics, genetic information (ApoE4) and CSF biomarkers explaining 57% of outcome variance in out-of sample predictions. The highest performance for A  42/40 status classification was achieved for a combination of demographics, ApoE4, and a memory score while usage of structural MRI further improved the classification of individual patient's pTau status.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198