Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Baranzini, Sergio E. (2022): Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. In: Cell, Bd. 185, Nr. 19: 3467-+

Abstract

Changes in gut microbiota have been associated with several diseases. Here, the International Multiple Scle-rosis Microbiome Study (iMSMS) studied the gut microbiome of 576 MS patients (36% untreated) and genet-ically unrelated household healthy controls (1,152 total subjects). We observed a significantly increased proportion of Akkermansia muciniphila, Ruthenibacterium lactatiformans, Hungatella hathewayi, and Eisen-bergiella tayi and decreased Faecalibacterium prausnitzii and Blautia species. The phytate degradation pathway was over-represented in untreated MS, while pyruvate-producing carbohydrate metabolism path-ways were significantly reduced. Microbiome composition, function, and derived metabolites also differed in response to disease-modifying treatments. The therapeutic activity of interferon-b may in part be associated with upregulation of short-chain fatty acid transporters. Distinct microbial networks were observed in un-treated MS and healthy controls. These results strongly support specific gut microbiome associations with MS risk, course and progression, and functional changes in response to treatment.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198