Automatic covariance pattern analysis outperforms visual reading of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy

Buchert, Ralph; Wegner, Florian; Huppertz, Hans-Juergen; Berding, Georg; Brendel, Matthias; Apostolova, Ivayla; Buhmann, Carsten; Dierks, Alexander; Katzdobler, Sabrina; Klietz, Martin; Levin, Johannes; Mahmoudi, Nima; Rinscheid, Andreas; Rogozinski, Sophia; Rumpf, Jost-Julian; Schneider, Christine; Stoecklein, Sophia; Spetsieris, Phoebe G.; Eidelberg, David; Wattjes, Mike P.; Sabri, Osama; Barthel, Henryk und Hoeglinger, Guenter (2023): Automatic covariance pattern analysis outperforms visual reading of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy. In: Movement Disorders, Bd. 38, Nr. 10: S. 1901-1913

Abstract

Background: To date, studies on positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS). Objectives: To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice. Methods: This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern. Results: Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample. Conclusions: Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. (C) 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198