APOE and immunity: Research highlights

Kloske, Courtney M.; Barnum, Christopher J.; Batista, Andre F.; Bradshaw, Elizabeth M.; Brickman, Adam M.; Bu, Guojun; Dennison, Jessica; Gearon, Mary D.; Goate, Alison M.; Haass, Christian; Heneka, Michael T.; Hu, William T.; Huggins, Lenique K. L.; Jones, Nahdia S.; Koldamova, Radosveta; Lemere, Cynthia A.; Liddelow, Shane A.; Marcora, Edoardo; Marsh, Samuel E.; Nielsen, Henrietta M.; Petersen, Kellen K.; Petersen, Melissa; Pina-Escudero, Stefanie D.; Qiu, Wei Qiao; Quiroz, Yakeel T.; Reiman, Eric; Sexton, Claire; Tansey, Malu Gamez; Julia, T. C. W.; Teunissen, Charlotte E.; Tijms, Betty M.; van der Kant, Rik; Wallings, Rebecca; Weninger, Stacie C.; Wharton, Whitney; Wilcock, Donna M.; Wishard, Tyler James; Worley, Susan L.; Zetterberg, Henrik und Carrillo, Maria C. (2023): APOE and immunity: Research highlights. In: Alzheimers & Dementia

Abstract

INTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTSDuring the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor alpha [TNF alpha]). DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198