Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Lauerer, Markus; Bussas, Matthias; Pongratz, Viola; Berthele, Achim; Kirschke, Jan S.; Wiestler, Benedikt; Zimmer, Claus; Hemmer, Bernhard und Muehlau, Mark (2023): Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume. In: Annals of Clinical and Translational Neurology, Bd. 10, Nr. 1: S. 130-135

Abstract

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing-remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198