A Short Progressive Supranuclear Palsy Quality of Life Scale

Jensen, Ida ; Stiel, Stephanie; Bebermeier, Sarah; Schrag, Anette ; Greten, Stephan ; Doll‐Lee, Johanna ; Wegner, Florian; Ye, Lan; Heine, Johanne; Krey, Lea; Höllerhage, Matthias; Süß, Patrick; Winkler, Jürgen; Berg, Daniela; Paschen, Steffen; Tönges, Lars ; Gruber, Doreen; Gandor, Florin ; Jost, Wolfgang H. ; Kühn, Andrea A.; Claus, Inga; Warnecke, Tobias; Pedrosa, David J.; Eggers, Carsten; Trenkwalder, Claudia; Classen, Joseph; Schwarz, Johannes; Pötter‐Nerger, Monika ; Kassubek, Jan ; Schnitzler, Alfons; Höglinger, Günter U. und Klietz, Martin (2024): A Short Progressive Supranuclear Palsy Quality of Life Scale. In: Movement Disorders, Bd. 39, Nr. 9: S. 1602-1609

Abstract

Objective : The Progressive Supranuclear Palsy quality of life scale (PSP-QoL) has been shown to be a useful tool for capturing health-related quality of life of patients in “everyday life” and in progressive supranuclear palsy (PSP) research. However, at 45 items in length, the questionnaire can take a long time, exhausting PSP patients, in particular if cognitive impaired, which can have a negative impact on the assessment. The aim of this study was to establish a condensed version of the PSP-QoL for research and routine clinical care. Methods : In this retrospective study, data originating from a German cohort of PSP patients was analyzed. Data from 245 PSP patients were included in this study. The short PSP-QoL questionnaire was created using a two-factor solution and item-total and inter-item correlations for mental and physical aspects of daily living of the PSP-QoL followed by confirmatory factor analysis. Results : The final scale included 12 items representing mental (five items) and physical symptoms (seven items). The specified two-factor model displayed an excellent fit in the confirmatory factor analysis. The short Progressive Supranuclear Palsy Quality of Life scale (PSP-ShoQoL) correlated moderately with the PSP Rating Scale (r [243] = 0.514, P < 0.001) and Geriatric depression scale (r [231] = 0.548, P < 0.001). Sensitivity to change confirmed a significant decrease in QoL after 12 months. Discussion : In this study, we created a 12-item PSP-ShoQoL designed to “facilitate” daily clinical work that correlated strongly with the PSP-QoL and was sensitive to change. © 2024 International Parkinson and Movement Disorder Society.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0885-3185
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198