Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts

Shao, Kai; Hu, Xiaochen; Kleineidam, Luca; Stark, Melina; Altenstein, Slawek; Amthauer, Holger; Boecker, Henning; Buchert, Ralph; Buerger, Katharina; Butryn, Michaela; Cai, Yanning; Cai, Yue; Cosma, Nicoleta Carmen; Chen, Guanqun; Chen, Zhigeng; Daamen, Marcel; Drzezga, Alexander; Düzel, Emrah; Essler, Markus; Ewers, Michael ; Fliessbach, Klaus; Gaertner, Florian C.; Glanz, Wenzel; Guo, Tengfei; Hansen, Niels; He, Beiqi; Janowitz, Daniel; Kilimann, Ingo; Krause, Bernd J.; Lan, Guoyu; Lange, Catharina; Laske, Christoph; Li, Yuxia; Li, Ruixian; Liu, Lin; Lu, Jie; Meng, Fansheng; Munk, Matthias H.; Peters, Oliver; Perneczky, Robert ; Priller, Josef; Ramirez, Alfredo; Rauchmann, Boris‐Stephan; Reimold, Matthias; Rominger, Axel ; Rostamzadeh, Ayda; Roy‐Kluth, Nina; Schneider, Anja; Spottke, Annika; Spruth, Eike Jakob; Sun, Pan; Teipel, Stefan; Wang, Xiao; Wei, Min; Wei, Yongzhe; Wiltfang, Jens; Yan, Shaozhen; Yang, Jie; Yu, Xianfeng; Zhang, Mingkai; Zhang, Liang; Wagner, Michael ; Jessen, Frank; Han, Ying und Kuhn, Elizabeth (2024): Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts. In: Alzheimer's & Dementia, Bd. 20, Nr. 9: S. 5926-5939

Abstract

Introduction : Subjective cognitive decline (SCD) in amyloid-positive (Aβ+) indi-viduals was proposed as a clinical indicator of Stage 2 in the Alzheimer’s disease(AD) continuum, but this requires further validation across cultures, measures, andrecruitment strategies. Methods : Eight hundred twenty-one participants from SILCODE and DELCODEcohorts, including normal controls (NC) and individuals with SCD recruited from thecommunity or from memory clinics, underwent neuropsychological assessments overup to 6 years. Amyloid positivity was derived from positron emission tomography orplasma biomarkers. Global cognitive change was analyzed using linear mixed-effectsmodels. Results : In the combined and stratified cohorts, Aβ+ participants with SCD showedsteeper cognitive decline or diminished practice effects compared with NC or Aβ− par-ticipants with SCD. These findings were confirmed using different operationalizationsof SCD and amyloid positivity, and across different SCD recruitment settings. Discussion : Aβ+ individuals with SCD in German and Chinese populations showedgreater global cognitive decline and could be targeted for interventional trials.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) ; Medizin > Klinikum der LMU München > Klinik und Poliklinik für Nuklearmedizin ; Medizin > Klinikum der LMU München > Klinik und Poliklink für Psychiatrie und Psychotherapie ; Medizin > Klinikum der LMU München > Klinik und Poliklinik für Radiologie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198