Akinetic crisis and withdrawal syndromes

Pötter-Nerger, Monika ; Löhle, Matthias und Höglinger, Günter (2024): Akinetic crisis and withdrawal syndromes. Guideline “Parkinson’s disease” of the German Society of Neurology. In: Journal of Neurology, Bd. 271, Nr. 10: S. 6485-6493

Abstract

The akinetic crisis is a well-known, rare, potentially life-threatening condition in Parkinson’s disease with subacute worsening of akinesia, rigidity, fever, impaired consciousness, accompanying vegetative symptoms and transient dopa-resistance. The akinetic crisis was historically supposed to be a “withdrawal syndrome” in the sense of discontinuation of dopaminergic medication. Recently, other “withdrawal syndromes” as the specific “dopamine agonist withdrawal syndrome” or “deep brain stimulation withdrawal syndrome” have been described as emergency situations with specific subacute symptom constellations. All three conditions require immediate start of the adequate therapy to improve the prognosis. Here, the diagnostic criteria and treatment options of these three acute, severely disabling syndromes will be reported along the current guidelines of the German Parkinson Guideline Group.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-5354
• Bemerkung: Mitverfasser: German Parkinson‘s Guideline Group
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198