ORCID: https://orcid.org/0009-0007-4379-4436; Unterrainer, Marcus
ORCID: https://orcid.org/0000-0002-8238-1198; Eilsberger, Friederike; Jurkschat, Klaus; Wängler, Carmen; Wängler, Björn; Schirrmacher, Ralf; Tiling, Maximilian W.; Sheikh, Gabriel T.; Mehrens, Dirk
ORCID: https://orcid.org/0000-0001-5114-8935; Brendel, Matthias
ORCID: https://orcid.org/0000-0002-9247-2843; Rübenthaler, Johannes; Auernhammer, Christoph J.; Spitzweg, Christine; Unterrainer, Lena M. und Holzgreve, Adrien
ORCID: https://orcid.org/0000-0002-9566-8438
(2025):
PET/CT imaging of differentiated and medullary thyroid carcinoma using the novel SSTR-targeting peptide [18F]SiTATE – first clinical experiences.
In: European Journal of Nuclear Medicine and Molecular Imaging, Bd. 52: S. 900-912
[PDF, 1MB]

Abstract
Purpose : The novel 18F-labeled somatostatin receptor (SSTR)-directed radiotracer [18F]SiTATE demonstrated promising results for the imaging of various SSTR-expressing tumor types. Although thyroid carcinomas (TC) express SSTR, data on [18F]SiTATE PET/CT imaging in TC are lacking. This study explores the use of [18F]SiTATE PET/CT in a patient cohort with histologically proven TC. Methods : As part of a prospective observational study at a single tertiary cancer center, 21 patients with TC (10 medullary (MTC) and 11 differentiated (DTC)) who underwent at least one [18F]SiTATE PET/CT were included (37 scans in total). Mean SUVmax and SUVmean of tumoral lesions, mean total-tumor-volume (TTV), and whole-body (WB)-SUVmax and WB-SUVmean on PET with their standard deviations (SDs) were determined. PET parameters were correlated to clinical parameters including tumor marker levels (thyroglobulin for DTC, calcitonin for MTC). Results : 89 lesions were included in the analysis. Metastases were localized in the bone, lymph nodes, lung, soft tissue, and thyroid bed. Osseous (31 lesions; SUVmax 8.6 ± 8.0; SUVmean 5.8 ± 5.4) and nodal (37 lesions; SUVmax 8.7 ± 7.8; SUVmean 5.7 ± 5.4) metastases showed the highest uptake. The MTC disease burden on PET significantly correlated with the calcitonin tumor marker level (e.g., TTV: r = 0.771, r2 = 0.594, p = 0.002). For DTC, no such correlation was present. Conclusion : Our data demonstrate high feasibility of [18F]SiTATE PET/CT in a small cohort of patients with MTC and DTC. The use of [18F]SiTATE may overcome logistical disadvantages of 68Ga-based tracers and facilitate SSTR-targeted PET/CT imaging of thyroid carcinoma.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin > Munich Cluster for Systems Neurology (SyNergy)
Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik IV (Endokrinologie, Nephrologie, weitere Sektionen) Medizin > Klinikum der LMU München > Klinik und Poliklinik für Nuklearmedizin Medizin > Klinikum der LMU München > Klinik und Poliklinik für Radiologie |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-123275-6 |
ISSN: | 1619-7070 |
Sprache: | Englisch |
Dokumenten ID: | 123275 |
Datum der Veröffentlichung auf Open Access LMU: | 23. Dez. 2024 06:47 |
Letzte Änderungen: | 11. Mrz. 2025 13:04 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |