Frontoparietal network integrity supports cognitive function in pre‐symptomatic frontotemporal dementia

Liu, Xulin ; Jones, Peter Simon; Pasternak, Maurice; Masellis, Mario; Bouzigues, Arabella; Russell, Lucy L.; Foster, Phoebe H.; Ferry‐Bolder, Eve; Swieten, John van; Jiskoot, Lize; Seelaar, Harro; Sanchez‐Valle, Raquel; Laforce, Robert; Graff, Caroline; Galimberti, Daniela; Vandenberghe, Rik; Mendonça, Alexandre de; Tiraboschi, Pietro; Santana, Isabel; Gerhard, Alexander; Levin, Johannes ; Sorbi, Sandro; Otto, Markus; Pasquier, Florence; Ducharme, Simon; Butler, Chris; Le Ber, Isabelle; Finger, Elizabeth; Tartaglia, Maria Carmela; Synofzik, Matthis; Moreno, Fermin; Borroni, Barbara; Rohrer, Jonathan D.; Tsvetanov, Kamen A. und Rowe, James B. (2024): Frontoparietal network integrity supports cognitive function in pre‐symptomatic frontotemporal dementia. Multimodal analysis of brain function, structure, and perfusion. In: Alzheimer's & Dementia, Bd. 20, Nr. 12: S. 8576-8594

Abstract

Introduction

Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.

Methods

We included 207 pre-symptomatic genetic mutation carriers and 188 relatives without mutations. The gray matter volume, cerebral perfusion, and resting-state functional network maps were co-analyzed using linked independent component analysis (LICA). Multiple regression analysis was used to investigate the relationship of LICA components to genetic status and cognition.

Results

Pre-symptomatic mutation carriers showed an age-related decrease in the left frontoparietal network integrity, while non-carriers did not. Executive functions of mutation carriers became dependent on the left frontoparietal network integrity in older age.

Discussion

The frontoparietal network integrity of pre-symptomatic mutation carriers showed a distinctive relationship to age and cognition compared to non-carriers, suggesting a contribution of the network integrity to brain resilience.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Bemerkung: with The GENFI consortium
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198