Dementia risk reduction in the African context

Udeh‐Momoh, Chinedu T.; Maina, Rachel; Anazodo, Udunna C.; Akinyemi, Rufus; Atwoli, Lukoye; Baker, Laura; Bassil, Darina; Blackmon, Karen; Bosire, Edna; Chemutai, Gloria; Crivelli, Lucia; Eze, Laz U.; Ibanez, Agustin; Kafetsouli, Dimitra; Karikari, Thomas K.; Khakali, Linda; Kumar, Manasi; Lengyel, Imre; Jager Loots, Celeste A. de; Mangialasche, Francesca; Mbugua, Sylvia; Merali, Zul; Mielke, Michelle; Mostert, Cyprian; Muthoni, Eunice; Nesic‐Taylor, Olivera; Ngugi, Anthony; Nguku, Samuel; Ogunniyi, Adesola; Ogunyemi, Adedoyin; Okonkwo, Ozioma C.; Okubadejo, Njideka; Perneczky, Robert ; Peto, Tunde; Riang'a, Roselyter M.; Saleh, Mansoor; Sayed, Shaheen; Shah, Jasmit; Shah, Sheena; Solomon, Alina; Thesen, Thomas; Trepel, Dominic; Ucheagwu, Valentine; Valcour, Victor; Waa, Sheila; Watermeyer, Tamlyn; Yokoyama, Jennifer; Zetterberg, Henrik und Kivipelto, Miia (2024): Dementia risk reduction in the African context. Multi‐national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project). In: Alzheimer's & Dementia, Bd. 20, Nr. 12: S. 8987-9003

Abstract

Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) ; Medizin > Klinikum der LMU München > Klinik und Poliklink für Psychiatrie und Psychotherapie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198