ORCID: https://orcid.org/0009-0009-4542-3000; Klietz, Martin ORCID: https://orcid.org/0000-0002-3054-9905; Greten, Stephan ORCID: https://orcid.org/0000-0003-0638-8571; Piot, Ines A.; Jensen, Ida ORCID: https://orcid.org/0009-0006-0270-0029; Wegner, Florian; Ye, Lan; Krey, Lea; Höllerhage, Matthias; Pötter‐Nerger, Monika ORCID: https://orcid.org/0000-0001-7680-2147; Zeitzschel, Molly; Hagena, Keno; Kassubek, Jan ORCID: https://orcid.org/0000-0002-7106-9270; Süß, Patrick; Winkler, Jürgen; Berg, Daniela; Paschen, Steffen; Tönges, Lars ORCID: https://orcid.org/0000-0001-6621-144X; Gruber, Doreen; Gandor, Florin ORCID: https://orcid.org/0000-0003-2874-9817; Jost, Wolfgang H. ORCID: https://orcid.org/0000-0002-8574-3297; Kühn, Andrea A.; Claus, Inga; Warnecke, Tobias; Pedrosa, David J.; Eggers, Carsten; Trenkwalder, Claudia; Classen, Joseph; Schwarz, Johannes; Schnitzler, Alfons; Krause, Patricia ORCID: https://orcid.org/0000-0001-9063-0556; Schneider, Anja ORCID: https://orcid.org/0000-0001-9540-8700; Brandt, Moritz; Falkenburger, Björn; Zerr, Inga; Bähr, Mathias; Weidinger, Endy; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Katzdobler, Sabrina ORCID: https://orcid.org/0000-0002-3512-5984; Düzel, Emrah; Glanz, Wenzel; Teipel, Stefan; Kilimann, Ingo; Prudlo, Johannes; Gasser, Thomas; Brockmann, Kathrin ORCID: https://orcid.org/0000-0002-7515-8596; Spottke, Annika; Esser, Anna; Petzold, Gabor C.; Respondek, Gesine ORCID: https://orcid.org/0000-0002-6851-6164 und Höglinger, Günter U. ORCID: https://orcid.org/0000-0001-7587-6187
(2025):
A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.
In: Movement Disorders Clinical Practice [Forthcoming]
Abstract
Background : Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing.
Objectives : To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP.
Methods : The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed.
Results : Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = −0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022).
Conclusions : The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Munich Cluster for Systems Neurology (SyNergy)
Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 2330-1619 |
| Sprache: | Englisch |
| Dokumenten ID: | 124736 |
| Datum der Veröffentlichung auf Open Access LMU: | 30. Mrz. 2025 16:36 |
| Letzte Änderungen: | 30. Mrz. 2025 16:36 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
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