SCD‐plus features and AD biomarkers in cognitively unimpaired samples: A meta‐analytic approach for nine cohort studies

Kuhn, Elizabeth ; Klinger, Hannah M. ; Amariglio, Rebecca E.; Wagner, Michael; Jessen, Frank; Düzel, Emrah; Heneka, Michael T.; Chételat, Gael ; Rentz, Dorene M.; Sperling, Reisa A.; Ebenau, Jarith L.; Butterbrod, Elke; Van Der Flier, Wiesje M. ; Sikkes, Sietske A. M.; Teunnissen, Charlotte E. ; Van Harten, Argonde C. ; Van De Giessen, Elsmarieke M. ; Rami, Lorena ; Tort, Adria ; Sánchez Benavides, Gonzalo ; Gifford, Katherine A. ; Van Hulle, Carol und Buckley, Rachel F. (2025): SCD‐plus features and AD biomarkers in cognitively unimpaired samples: A meta‐analytic approach for nine cohort studies. In: Alzheimer's & Dementia [Forthcoming]

Abstract

Introduction: Specific features of subjective cognitive decline (SCD-plus) have been proposed to indicate an increased risk of preclinical Alzheimer's disease (AD). However, few studies have examined how these features relate to AD biomarkers in cognitively unimpaired (CU) older adults.

Methods: Meta-analyses were performed using cross-sectional data from nine cohorts (n = 7219, mean age (SD): 71.17 (5.9), 56.5% female) to determine associations of SCD-plus features with positron emission tomography (PET)– or cerebrospinal fluid (CSF)–derived amyloid beta (Aβ) and tau biomarkers.

Results: Participants with preclinical AD (community-based only) were more likely to fulfill SCD-plus features. The presence of self-reported memory decline, associated concern/worry, and a higher number of fulfilled features were all associated with high Aβ levels. Only the latter was associated with abnormal tau.

Discussion: Simultaneous endorsement of multiple SCD-plus features is a robust indicator of abnormal AD biomarkers in CU older adults, whereas isolated SCD features seem only sensitive to elevated Aβ, supporting their value as early behavioral markers of preclinical AD.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Bemerkung: with the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study of ageing, A4 Study Team, DELCODE Study, Harvard Aging Brain Study and on behalf of the SCD-plus Amyloid & Tau working group within the ISTAART Subjective Cognitive Decline Professional Interest Area.
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198