Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease

Leuzy, Antoine; Bollack, Ariane; Pellegrino, Daniela; Teunissen, Charlotte E.; La Joie, Renaud; Rabinovici, Gil D.; Franzmeier, Nicolai ; Johnson, Keith; Barkhof, Frederik; Shaw, Leslie M.; Arkhipenko, Alexander; Schindler, Suzanne E.; Honig, Lawrence S.; Moscoso Rial, Alexis; Schöll, Michael; Zetterberg, Henrik; Blennow, Kaj; Hansson, Oskar und Farrar, Gill (2025): Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease. In: Alzheimer's & Dementia, Bd. 21, Nr. 3, e14528

Abstract

Amyloid-β (Aβ) positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) biomarkers are now established tools in the diagnostic workup of patients with Alzheimer's disease (AD), and their use is anticipated to increase with the introduction of new disease-modifying therapies. Although these biomarkers are comparable alternatives in research settings to determine Aβ status, biomarker testing in clinical practice requires careful consideration of the strengths and limitations of each modality, as well as the specific clinical context, to identify which test is best suited for each patient. This article provides a comprehensive review of the pathologic processes reflected by Aβ-PET and CSF biomarkers, their performance, and their current and future applications and contexts of use. The primary aim is to assist clinicians in making better-informed decisions about the suitability of each biomarker in different clinical situations, thereby reducing the risk of misdiagnosis or incorrect interpretation of biomarker results.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Institut für Schlaganfall- und Demenzforschung (ISD)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198