Cross‐country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia

Boer, Liset de ; Jiskoot, Lize C.; Seelaar, Harro; Swieten, John C. van; Ibanez, Agustin; Maito, Marcelo; Fittipaldi, Sol; Houwer, Julie F. H. De; Swartenbroekx, Tine; Boesjes, Pam A.; Convery, Rhian S.; Ferry‐Bolder, Eve; Foster, Phoebe; Bouzigues, Arabella; Chisman‐Russell, Lucy; Berg, Esther van den; Papma, Janne; Franzen, Sanne; Bourdage, Renelle; Rowe, James B.; Borroni, Barbara ; Galimberti, Daniela ; Tiraboschi, Pietro ; Masellis, Mario; Finger, Elizabeth ; Laforce, Robert; Graff, Caroline; Gerhard, Alexander; Sanchez‐Valle, Raquel; Mendonça, Alexandre; Moreno, Fermin; Synofzik, Matthis; Vandenberghe, Rik; Ducharme, Simon; Ber, Isabelle Le; Levin, Johannes; Lebouvier, Thibaud; Nacmias, Benedetta; Otto, Markus; Butler, Christopher R.; Santana, Isabel; Bertoux, Maxime; Tartaglia, M. Carmela; Rohrer, Jonathan D. und Poos, Jackie M. (2025): Cross‐country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia. In: Alzheimer's & Dementia, Bd. 21, Nr. 10, e70741

Abstract

INTRODUCTION

We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.

METHODS

An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries.

REULTS

Country accounted for 18%–18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found.

DISCUSSION

These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1552-5260
• Bemerkung: the GENFI Consortium
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198