ORCID: https://orcid.org/0000-0001-5503-6308; Gellersen, Helena M.; Polk, Sarah E.; Lattmann, René; Wuestefeld, Anika; Wisse, Laura E. M.; Glenn, Trevor; Yakupov, Renat ORCID: https://orcid.org/0000-0002-3868-284X; Stark, Melina ORCID: https://orcid.org/0009-0005-3812-023X; Kleineidam, Luca ORCID: https://orcid.org/0009-0006-3309-6856; Roeske, Sandra ORCID: https://orcid.org/0000-0002-8262-4356; Morgado, Barbara Marcos; Esselmann, Hermann; Brosseron, Frederic ORCID: https://orcid.org/0000-0003-3137-7516; Ramirez, Alfredo ORCID: https://orcid.org/0000-0003-4991-763X; Lüsebrink, Falk; Synofzik, Matthis ORCID: https://orcid.org/0000-0002-2280-7273; Schott, Björn H. ORCID: https://orcid.org/0000-0002-8237-4481; Schmid, Matthias C.; Hetzer, Stefan ORCID: https://orcid.org/0000-0002-1773-1518; Dechent, Peter ORCID: https://orcid.org/0009-0006-4005-3352; Scheffler, Klaus ORCID: https://orcid.org/0000-0001-6316-8773; Ewers, Michael ORCID: https://orcid.org/0000-0001-5231-1714; Hellmann‐Regen, Julian; Ersözlü, Ersin ORCID: https://orcid.org/0000-0001-6503-5894; Spruth, Eike J. ORCID: https://orcid.org/0000-0002-8976-7309; Gemenetzi, Maria; Fliessbach, Klaus ORCID: https://orcid.org/0000-0002-0183-7510; Bartels, Claudia; Rostamzadeh, Ayda ORCID: https://orcid.org/0000-0001-5189-134X; Glanz, Wenzel ORCID: https://orcid.org/0000-0002-5865-4176; Incesoy, Enise I. ORCID: https://orcid.org/0000-0003-2014-4098; Janowitz, Daniel ORCID: https://orcid.org/0009-0003-4090-547X; Rauchmann, Boris‐Stephan; Kilimann, Ingo ORCID: https://orcid.org/0000-0002-3269-4452; Sodenkamp, Sebastian; Coenjaerts, Marie; Spottke, Annika ORCID: https://orcid.org/0000-0001-9854-2972; Peters, Oliver ORCID: https://orcid.org/0000-0003-0568-2998; Priller, Josef ORCID: https://orcid.org/0000-0001-7596-0979; Schneider, Anja ORCID: https://orcid.org/0000-0001-9540-8700; Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330; Buerger, Katharina ORCID: https://orcid.org/0000-0002-5898-9953; Perneczky, Robert ORCID: https://orcid.org/0000-0003-1981-7435; Teipel, Stefan ORCID: https://orcid.org/0000-0002-3586-3194; Laske, Christoph ORCID: https://orcid.org/0009-0009-3434-936X; Wagner, Michael ORCID: https://orcid.org/0000-0003-2589-6440; Ziegler, Gabriel; Jessen, Frank ORCID: https://orcid.org/0000-0003-1067-2102; Düzel, Emrah ORCID: https://orcid.org/0000-0002-0139-5388 und Berron, David ORCID: https://orcid.org/0000-0003-1558-1883
(2025):
Disease stage–specific atrophy markers in Alzheimer's disease.
In: Alzheimer's & Dementia, Bd. 21, Nr. 7, e70482
Abstract
INTRODUCTION
Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrophy markers for different intended uses.
METHODS
We included 363 older adults; cognitively unimpaired individuals who were negative or positive for amyloid beta (Aβ) and Aβ-positive patients with subjective cognitive decline, mild cognitive impairment, or dementia of the Alzheimer type. MRI and neuropsychological assessments were administered annually for up to 3 years.
RESULTS
Accelerated atrophy of medial temporal lobe subregions was evident already during preclinical AD. Symptomatic disease stages most notably differed in their hippocampal and parietal atrophy signatures. Atrophy–cognition relationships varied by intended use and disease stage.
DISCUSSION
With the appropriate marker, MRI can detect abnormal atrophy already during preclinical AD. To optimize performance, atrophy markers should be tailored to the targeted disease stage and intended use.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Munich Cluster for Systems Neurology (SyNergy) |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 1552-5260 |
| Sprache: | Englisch |
| Dokumenten ID: | 129941 |
| Datum der Veröffentlichung auf Open Access LMU: | 01. Dez. 2025 08:49 |
| Letzte Änderungen: | 01. Dez. 2025 08:49 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 425899996 |
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