ORCID: https://orcid.org/0000-0003-1584-7477; Coomans, Emma M.; Apostolova, Liana G.; Baker, Suzanne L.; Barthel, Henryk; Beach, Thomas G.; Benzinger, Tammy L. S. ORCID: https://orcid.org/0000-0002-8114-0552; Betthauser, Tobey ORCID: https://orcid.org/0000-0001-8856-1352; Bischof, Gérard N.; Bottlaender, Michel ORCID: https://orcid.org/0000-0002-2890-3653; Bourgeat, Pierick ORCID: https://orcid.org/0000-0002-2605-4766; Braber, Anouk den; Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843; Brickman, Adam M. ORCID: https://orcid.org/0000-0002-5125-8226; Cash, David M. ORCID: https://orcid.org/0000-0001-7833-616X; Carrillo, Maria C.; Coath, William; Christian, Bradley T. ORCID: https://orcid.org/0000-0002-9653-559X; Dickerson, Brad C. ORCID: https://orcid.org/0000-0002-5958-3445; Dore, Vincent ORCID: https://orcid.org/0000-0002-8051-0558; Drzezga, Alexander ORCID: https://orcid.org/0000-0001-6018-716X; Feizpour, Azadeh ORCID: https://orcid.org/0000-0003-0826-4011; Flier, Wiesje M. van der ORCID: https://orcid.org/0000-0001-8766-6224; Franzmeier, Nicolai ORCID: https://orcid.org/0000-0001-9736-2283; Frisoni, Giovanni B.; Garibotto, Valentina; Giessen, Elsmarieke van de ORCID: https://orcid.org/0000-0001-9956-4233; Domingo-Gispert, Juan; Gnoerich, Johannes ORCID: https://orcid.org/0000-0003-1554-7765; Gu, Yuna; Guan, Yihui; Hanseeuw, Bernard J.; Harrison, Theresa M.; Jack, Clifford R. ORCID: https://orcid.org/0000-0001-7916-622X; Jaeger, Elena ORCID: https://orcid.org/0009-0007-9387-3175; Jagust, William J. ORCID: https://orcid.org/0000-0002-4458-113X; Jansen, Willemijn J.; Joie, Renaud La ORCID: https://orcid.org/0000-0003-2581-8100; Johnson, Keith A.; Johnson, Sterling C. ORCID: https://orcid.org/0000-0002-8501-545X; Kennedy, Ian A.; Kim, Jun Pyo ORCID: https://orcid.org/0000-0003-4376-3107; Laere, Koen van ORCID: https://orcid.org/0000-0001-5200-7245; Lagarde, Julien ORCID: https://orcid.org/0000-0002-2018-261X; Lao, Patrick; Luchsinger, José A.; Kern, Silke; Kreisl, William C.; Malotaux, Vincent; Malpetti, Maura ORCID: https://orcid.org/0000-0001-8923-9656; Manly, Jennifer J.; Mao, Xiaoxie; Mattsson-Carlgren, Niklas ORCID: https://orcid.org/0000-0002-8885-7724; Petersen, Ron C.; Messerschmidt, Konstantin; Minguillon, Carolina; Mormino, Elizabeth M.; O’Brien, John T. ORCID: https://orcid.org/0000-0002-0837-5080; Palmqvist, Sebastian ORCID: https://orcid.org/0000-0002-9267-1930; Peretti, Debora E. ORCID: https://orcid.org/0000-0002-3033-8817; Petersen, Ron C. ORCID: https://orcid.org/0000-0002-8178-6601; Pijnenburg, Yolande A. L.; Pontecorvo, Michael J.; Poirier, Judes ORCID: https://orcid.org/0000-0002-8018-4545; Rabinovici, Gil D. ORCID: https://orcid.org/0000-0002-3626-4265; Rahmouni, Nesrine; Risacher, Shannon L. ORCID: https://orcid.org/0000-0002-3304-7943; Rosa-Neto, Pedro ORCID: https://orcid.org/0000-0001-9116-1376; Rosen, Howard; Rowe, Christopher C. ORCID: https://orcid.org/0000-0003-3910-2453; Rowe, James B. ORCID: https://orcid.org/0000-0001-7216-8679; Rullmann, Michael; Salman, Yasmine ORCID: https://orcid.org/0000-0002-8564-5136; Sarazin, Marie; Saykin, Andrew J. ORCID: https://orcid.org/0000-0002-1376-8532; Schneider, Julie A. ORCID: https://orcid.org/0000-0002-9482-1752; Schöll, Michael ORCID: https://orcid.org/0000-0001-7800-1781; Schott, Jonathan M. ORCID: https://orcid.org/0000-0003-2059-024X; Seo, Sang Won; Serrano, Geidy E.; Shcherbinin, Sergey; Shekari, Mahnaz; Skoog, Ingmar; Smith, Ruben ORCID: https://orcid.org/0000-0001-7147-0112; Sperling, Reisa A.; Spruyt, Laure ORCID: https://orcid.org/0000-0002-0618-5005; Stomrud, Erik; Strandberg, Olof; Therriault, Joseph; Xie, Fang ORCID: https://orcid.org/0000-0003-2667-281X; Vandenberghe, Rik ORCID: https://orcid.org/0000-0001-6237-2502; Villemagne, Victor L.; Villeneuve, Sylvia ORCID: https://orcid.org/0000-0003-2338-0467; Visser, Pieter Jelle ORCID: https://orcid.org/0000-0001-8008-9727; Vossler, Hillary ORCID: https://orcid.org/0009-0007-8693-1939; Young, Christina B.; Groot, Colin und Hansson, Oskar ORCID: https://orcid.org/0000-0001-8467-7286
(2025):
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
In: Nature Neuroscience, Bd. 28: S. 1610-1621
[PDF, 4MB]
Abstract
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer’s disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60 years to 80 years, tau PET positivity in a temporal composite region increased from 1.1% to 4.4% among CU amyloid-β (Aβ)-negative participants and from 17.4% to 22.2% among CU Aβ-positive participants. Across the same age span, tau PET positivity decreased from 68.0% to 52.9% in participants with MCI and from 91.5% to 74.6% in participants with dementia. Age, Aβ status, APOE ε4 carriership and female sex were all associated with a higher prevalence of tau PET positivity across groups. APOE ε4 carriership in CU individuals lowered the age at onset of both Aβ positivity and tau positivity by decades. Finally, we replicated these associations in an independent autopsy dataset (N = 5,072 from 3 cohorts).
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| EU Funded Grant Agreement Number: | 949570 |
| Fakultät: | Medizin > Munich Cluster for Systems Neurology (SyNergy) |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| URN: | urn:nbn:de:bvb:19-epub-129945-1 |
| ISSN: | 1097-6256 |
| Sprache: | Englisch |
| Dokumenten ID: | 129945 |
| Datum der Veröffentlichung auf Open Access LMU: | 01. Dez. 2025 08:59 |
| Letzte Änderungen: | 01. Dez. 2025 08:59 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
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