ORCID: https://orcid.org/0000-0003-2449-5530; Sondermann, Verena; Schniewind, Iñaki; Hähnel, Tom; Dinter, Elisabeth; Kleineidam, Luca ORCID: https://orcid.org/0009-0006-3309-6856; Stark, Melina ORCID: https://orcid.org/0009-0005-3812-023X; Schmid, Matthias; Sodenkamp, Sebastian; Laske, Christoph ORCID: https://orcid.org/0009-0009-3434-936X; Spruth, Eike; Priller, Josef ORCID: https://orcid.org/0000-0001-7596-0979; Janowitz, Daniel ORCID: https://orcid.org/0009-0003-4090-547X; Bürger, Katharina; Kilimann, Ingo ORCID: https://orcid.org/0000-0002-3269-4452; Teipel, Stefan ORCID: https://orcid.org/0000-0002-3586-3194; Storch, Alexander; Hansen, Niels ORCID: https://orcid.org/0000-0001-5785-9594; Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330; Glanz, Wenzel ORCID: https://orcid.org/0000-0002-5865-4176; Düzel, Emrah ORCID: https://orcid.org/0000-0002-0139-5388; Preis, Lukas ORCID: https://orcid.org/0000-0001-7601-6410; Peters, Oliver ORCID: https://orcid.org/0000-0003-0568-2998; Hellmann‐Regen, Julian; Wagner, Michael ORCID: https://orcid.org/0000-0003-2589-6440; Bernhardt, Alexander ORCID: https://orcid.org/0000-0002-2572-5062; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Petzold, Gabor C. ORCID: https://orcid.org/0000-0002-0145-8641; Kronmüller, Marie; Gamez, Anna; Spottke, Annika ORCID: https://orcid.org/0000-0001-9854-2972; Brosseron, Frederic ORCID: https://orcid.org/0000-0003-3137-7516; Rostamzadeh, Ayda ORCID: https://orcid.org/0000-0001-5189-134X; Jessen, Frank ORCID: https://orcid.org/0000-0003-1067-2102; Hermann, Andreas; Fliessbach, Klaus ORCID: https://orcid.org/0000-0002-0183-7510; Schneider, Anja ORCID: https://orcid.org/0000-0001-9540-8700 und Falkenburger, Björn H. ORCID: https://orcid.org/0000-0002-2387-526X
(2026):
Alpha‐synuclein quantitative seed amplification assay predicts conversion to dementia.
In: Alzheimer's & Dementia, Bd. 22, Nr. 1, e71167
[PDF, 598kB]
Abstract
INTRODUCTION:
The alpha-synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology in living patients.
METHODS:
In addition to the “standard” SAA, we developed a quantitative SAA (qnSAA) and measured 432 CSF samples (216 baseline–follow-up pairs).
RESULTS:
qnSAA results correlated with cognitive performance. Seventy-five percent of participants with fast qnSAA kinetics converted to dementia in the observed interval. Overall, participants with fast qnSAA kinetics accounted for 27.3% of dementia converters in the entire cohort.
DISCUSSION:
Findings demonstrate promising properties of qnSAA measurements in a cohort of patients at risk for dementia. qnSAA results showed improved prognostic relevance and have potential to measure target engagement of therapies against Lewy body pathology.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Munich Cluster for Systems Neurology (SyNergy)
Medizin > Institut für Schlaganfall- und Demenzforschung (ISD) Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| URN: | urn:nbn:de:bvb:19-epub-132192-8 |
| ISSN: | 1552-5260 |
| Sprache: | Englisch |
| Dokumenten ID: | 132192 |
| Datum der Veröffentlichung auf Open Access LMU: | 16. Feb. 2026 09:55 |
| Letzte Änderungen: | 16. Feb. 2026 09:55 |
- Dokument bearbeiten
