Lessons from the Colombian kindred: rethinking Alzheimer's prevention

Fortea, Juan ; Llibre-Guerra, Jorge J. ; O'Connor, Antoinette und Levin, Johannes (2026): Lessons from the Colombian kindred: rethinking Alzheimer's prevention. In: Lancet Neurology, Bd. 25, Nr. 2: S. 117-119

Abstract

In The Lancet Neurology, Pierre N Tariot and colleagues present the Alzheimer's Prevention Initiative (API) Colombia Trial, a landmark public–private partnership, evaluating crenezumab in autosomal-dominant Alzheimer's disease (ADAD). The API ADAD Colombia Trial enrolled 252 members of the world's largest kindred in Medellín, Colombia, all carrying the PSEN1 Glu280Ala mutation, a population whose well characterised natural history, defined through decades of work by the late Francisco Lopera and colleagues, made it uniquely suited for a preventive intervention.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy) ; Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1474-4422
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198