ATP-dependent chromatosome remodeling

Maier, Verena K.; Chioda, Mariacristina und Becker, Peter B. (2008): ATP-dependent chromatosome remodeling. In: Biological Chemistry, Vol. 389, No. 4: pp. 345-352

Abstract

Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime. One important principle that endows chromatin with flexibility involves ATP-dependent `remodeling' factors, which alter DNA-histone interactions to form, disrupt or move nucleosomes. Remodeling is well documented at the nucleosomal level, but little is known about the action of remodeling factors in a more physiological chromatin environment. Recent findings suggest that some remodeling machines can reorganize even folded chromatin fibers containing the linker histone H1, extending the potential scope of remodeling reactions to the bulk of euchromatin.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine; Medicine > Adolf Butenandt Institute
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1431-6730
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English