The Long-Term Effect of Four Hours of Hyperventilation on Neurocognitive Performance and Lesion Size After Controlled Cortical Impact in Rats

Eberspaecher, Eva; Blobner, Manfred; Werner, Christian; Ruf, Stefanie; Eckel, Barbara; Engelhard, Kristin; Schmahl, Wolfgang W. und Gelb, Adrian W. (2010): The Long-Term Effect of Four Hours of Hyperventilation on Neurocognitive Performance and Lesion Size After Controlled Cortical Impact in Rats. In: Anesthesia and Analgesia, Bd. 110, Nr. 1: S. 181-187

Abstract

BACKGROUND: We investigated the effects of 4 h of posttraumatichyperventilation on neurocognitive performance, motor function, andcoordination as well as lesion volume in rats subjected to focaltraumatic brain injury.METHODS: After a 14-day training period with various neurocognitivetests including hole-board, beam walk, and beam balance, 21 maleSprague-Dawley rats (369 +/- 15 g) were anesthetized with halothane,tracheally intubated, their lungs mechanically ventilated, and subjectedto controlled cortical impact (1.75 mm depth, empty set 5 mm, 4 m/s).

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Geowissenschaften > Department für Geo- und Umweltwissenschaften > Kristallographie und Materialwissenschaft
• Themengebiete: 500 Naturwissenschaften und Mathematik > 550 Geowissenschaften, Geologie
• Sprache: Englisch