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Eberspaecher, Eva; Blobner, Manfred; Werner, Christian; Ruf, Stefanie; Eckel, Barbara; Engelhard, Kristin; Schmahl, Wolfgang W.; Gelb, Adrian W. (2010): The Long-Term Effect of Four Hours of Hyperventilation on Neurocognitive Performance and Lesion Size After Controlled Cortical Impact in Rats. In: Anesthesia and Analgesia, Vol. 110, No. 1: pp. 181-187
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BACKGROUND: We investigated the effects of 4 h of posttraumatichyperventilation on neurocognitive performance, motor function, andcoordination as well as lesion volume in rats subjected to focaltraumatic brain injury.METHODS: After a 14-day training period with various neurocognitivetests including hole-board, beam walk, and beam balance, 21 maleSprague-Dawley rats (369 +/- 15 g) were anesthetized with halothane,tracheally intubated, their lungs mechanically ventilated, and subjectedto controlled cortical impact (1.75 mm depth, empty set 5 mm, 4 m/s).