Pore formation by GSDMD is the effector mechanism of pyroptosis

Gaidt, Moritz M. und Hornung, Veit (2016): Pore formation by GSDMD is the effector mechanism of pyroptosis. In: Embo Journal, Bd. 35, Nr. 20: S. 2167-2169

Abstract

Pyroptosis is a unique, pro-inflammatory form of lytic cell death that is initiated by the activation of inflammatory caspases. The caspase substrate gasdermin D (GSDMD) plays a critical function in pyroptosis, yet the precise mode of action of this molecule in cell death execution remained unclear. Several recent reports, including a The EMBO Journal article, show that the caspase-matured N-terminal fragment of GSDMD is recruited to lipid membranes to form pore-like structures, which constitutes the key effector mechanism of pyroptotic cell death.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Biochemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0261-4189
• Sprache: Englisch