Translation regulation via nascent polypeptide-mediated ribosome stalling

Wilson, Daniel N.; Arenz, Stefan und Beckmann, Roland (2016): Translation regulation via nascent polypeptide-mediated ribosome stalling. In: Current Opinion in Structural Biology, Bd. 37: S. 123-133

Abstract

As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Interaction between the nascent polypeptide chain and the ribosomal tunnel can modulate the translation rate and induce translational stalling to regulate gene expression. In this article, we highlight recent structural insights into how the nascent polypeptide chain, either alone or in cooperation with co-factors, can interact with components of the ribosomal tunnel to regulate translation via inactivating the peptidyltransferase center of the ribosome and inducing ribosome stalling.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Biochemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0959-440X
• Sprache: Englisch