A chloride channel in rat and human axons

Strupp, Michael und Grafe, Peter (1991): A chloride channel in rat and human axons. In: Neuroscience Letters, Bd. 133, Nr. 2: S. 237-240

Abstract

Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at negative membrane potentials and 65 pS at positive potentials (symmetrical 150 mM CsCl). They were measurably for cations (PNa/PCs/PCl=0.1/0.2/1). Channel currents were independent of cytoplasmatic calcium concentration. Inactivation was not observed and gating was weakly voltage dependent. Cl− channels in human axons showed similar gating behavior but had a lower conductance.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Axon; Myelinated fiber; Patch clamp; Single chloride channel; Background conductance; Rat; Human
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit