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Singh, Vikramjeet; Sadler, Rebecca; Heindl, Steffanie; Llovera, Gemma; Roth, Stefan; Benakis, Corinne; Liesz, Arthur (2018): The gut microbiome primes a cerebroprotective immune response after stroke. In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 8: pp. 1293-1298
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Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome. Interestingly, the microbiome-mediated brain protection was absent in lymphocyte-deficient mice. These findings support the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.