Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; Lepennetier, Gildas; Engleitner, Thomas; Garg, Garima; Muschaweckh, Andreas; Mitsdoerffer, Meike; Koedel, Uwe; Hoechst, Bastian; Knolle, Percy; Gunzer, Matthias; Hemmer, Bernhard; Rad, Roland; Merkler, Doron und Korn, Thomas (2018): Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity. In: Nature Immunology, Bd. 19, Nr. 12: S. 1341-1351

Abstract

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G(+) cells were recruited to the CNS during experimental autoimmune encephalomyelitis (EAE), interacted with B cells that produced the cytokines GM-CSF and interleukin-6 (IL-6), and acquired properties of PMN-MDSCs in the CNS in a manner dependent on the signal transducer STAT3. Depletion of Ly6G(+) cells or dysfunction of Ly6G(+) cells through conditional ablation of STAT3 led to the selective accumulation of GM-CSF-producing B cells in the CNS compartment, which in turn promoted an activated microglial phenotype and lack of recovery from EAE. The frequency of CD138(+) B cells in the cerebrospinal fluid (CSF) of human subjects with multiple sclerosis was negatively correlated with the frequency of PMN-MDSCs in the CSF. Thus PMN-MDSCs might selectively control the accumulation and cytokine secretion of B cells in the inflamed CNS.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Munich Cluster for Systems Neurology (SyNergy)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1529-2908
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198