Abstract
Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's disease. The physiological functions of HCN1 and HCN2 channels in the nervous system have been analyzed using genetic knockout mouse models. By contrast, there are no such genetic studies for HCN3 channels so far. Here, we use a HCN3-deficient (HCN3(-/-)) mouse line, which has been previously generated in our group to examine the expression and function of this channel in the CNS. Specifically, we investigate the role of HCN3 channels for the regulation of circadian rhythmand for the determination of behavior. Contrary to previous suggestions we find that HCN3(-/-) mice show normal visual, photic, and non-photic circadian function. In addition, HCN3(-/-) mice are impaired in processing contextual information, which is characterized by attenuated long-term extinction of contextual fear and increased fear to a neutral context upon repeated exposure.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung |
| Fakultätsübergreifende Einrichtungen: | Center for Integrated Protein Science Munich (CIPSM) |
| Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| URN: | urn:nbn:de:bvb:19-epub-67219-6 |
| ISSN: | 1662-5099 |
| Sprache: | Englisch |
| Dokumenten ID: | 67219 |
| Datum der Veröffentlichung auf Open Access LMU: | 19. Jul. 2019, 12:22 |
| Letzte Änderungen: | 04. Nov. 2020, 13:49 |
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