| Juerjens, Gerrit; Schuler, Sören M. M.; Kurz, Michael; Petit, Sylvain; Couturier, Cedric; Jeannot, Frederic; Nguyen, Fabian; Wende, Raffael C.; Hammann, Peter E.; Wilson, Daniel N.; Bacque, Eric; Poeverlein, Christoph; Bauer, Armin (2018): Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A. In: Angewandte Chemie-International Edition, Vol. 57, No. 37: pp. 12157-12161 |
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Abstract
The total synthesis of the naturally occurring antibiotic GE81112A, a densely functionalized tetrapeptide, is reported. Comparison of spectral data with those of the natural product and the lack of biological activity of the synthesized compound led us to revise the published configuration of the 3-hydroxypipecolic acid moiety. This hypothesis was fully validated by the synthesis of the corresponding epimer.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Biochemistry |
| Research Centers: | Center for Integrated Protein Science Munich (CIPSM) |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 1433-7851 |
| Language: | English |
| ID Code: | 68172 |
| Deposited On: | 19. Jul 2019 12:24 |
| Last Modified: | 04. Nov 2020 13:50 |
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