Song, Mengmeng; Beyer, Leonie; Kaiser, Lena; Barthel, Henryk; Eimeren, Thilo van; Marek, Ken; Nitschmann, Alexander; Scheifele, Maximilian; Palleis, Carla; Respondek, Gesine; Kern, Maike; Biechele, Gloria; Hammes, Jochen; Bischof, Gèrard; Barbe, Michael; Onur, Özgür; Jessen, Frank; Saur, Dorothee; Schroeter, Matthias L.; Rumpf, Jost-Julian; Rullmann, Michael; Schildan, Andreas; Patt, Marianne; Neumaier, Bernd; Barret, Olivier ![]() ![]() ![]() ![]() |
| Creative Commons Attribution 1MB |
Abstract
The novel tau-PET tracer 18FPI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether 18FPI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. 18FPI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. 18FPI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 {\&} k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. 18FPI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-77073-6 |
Language: | English |
ID Code: | 77073 |
Deposited On: | 05. Nov 2021 13:34 |
Last Modified: | 26. Jan 2022 11:53 |
- BASE
- Song, Mengmeng
- Beyer, Leonie
- Kaiser, Lena
- Barthel, Henryk
- Eimeren, Thilo van
- Marek, Ken
- Nitschmann, Alexander
- Scheifele, Maximilian
- Palleis, Carla
- Respondek, Gesine
- Kern, Maike
- Biechele, Gloria
- Hammes, Jochen
- Bischof, Gèrard
- Barbe, Michael
- Onur, Özgür
- Jessen, Frank
- Saur, Dorothee
- Schroeter, Matthias L.
- Rumpf, Jost-Julian
- Rullmann, Michael
- Schildan, Andreas
- Patt, Marianne
- Neumaier, Bernd
- Barret, Olivier
- Madonia, Jennifer
- Russell, David S.
- Stephens, Andrew W.
- Mueller, Andre
- Roeber, Sigrun
- Herms, Jochen
- Bötzel, Kai
- Danek, Adrian
- Levin, Johannes
- Classen, Joseph
- Höglinger, Günter U.
- Bartenstein, Peter
- Villemagne, Victor
- Drzezga, Alexander
- Seibyl, John
- Sabri, Osama
- Boening, Guido
- Ziegler, Sibylle
- Brendel, Matthias
- Google Scholar
- Song, Mengmeng
- Beyer, Leonie
- Kaiser, Lena
- Barthel, Henryk
- Eimeren, Thilo van
- Marek, Ken
- Nitschmann, Alexander
- Scheifele, Maximilian
- Palleis, Carla
- Respondek, Gesine
- Kern, Maike
- Biechele, Gloria
- Hammes, Jochen
- Bischof, Gèrard
- Barbe, Michael
- Onur, Özgür
- Jessen, Frank
- Saur, Dorothee
- Schroeter, Matthias L.
- Rumpf, Jost-Julian
- Rullmann, Michael
- Schildan, Andreas
- Patt, Marianne
- Neumaier, Bernd
- Barret, Olivier
- Madonia, Jennifer
- Russell, David S.
- Stephens, Andrew W.
- Mueller, Andre
- Roeber, Sigrun
- Herms, Jochen
- Bötzel, Kai
- Danek, Adrian
- Levin, Johannes
- Classen, Joseph
- Höglinger, Günter U.
- Bartenstein, Peter
- Villemagne, Victor
- Drzezga, Alexander
- Seibyl, John
- Sabri, Osama
- Boening, Guido
- Ziegler, Sibylle
- Brendel, Matthias