Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis

Luo, Shanshan; Zhu, Rui; Yu, Ting; Fan, Heng; Hu, Yu; Mohanta, Sarajo Kumar und Hu, Desheng (18. Dezember 2019): Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis. In: Frontiers in Immunology, Bd. 10, 2938

Abstract

Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with lymphotoxin α1β+2 immune cells. The interaction initiates lymphoid neogenesis by recruiting immune cells to the site of inflammation and ultimately leads to the formation of TLOs. Mature TLOs harbor a segregated T-cell zone, B-cell follicles with an activated germinal center, follicular dendritic cells, and high endothelial venules, which architecturally resemble those in secondary lymphoid organs. Since CXCL13 and LTα1β2 play key roles in TLO neogenesis, they might constitute potential biomarkers of TLO activity. The well-developed TLOs actively regulate local immune responses and influence disease progression, and they are thereby regarded as the powerhouses of local immunity. In this review, we recapitulated the determinants for TLOs development, with great emphasis on the fundamental role of chronic inflammation and tissue-resident stromal cells for TLO neogenesis, hence offering guidance for therapeutic interventions in TLO-associated diseases.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Immunity; inflammation; atherosclerosis; tertiary lymphoid organs; adventitia
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1664-3224
• Sprache: Englisch