Abstract
Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of cancer cells has been proposed to help drive tumorigenesis, metastasis, recurrence and conventional therapy resistance. CSCs show self-renewal and flexible clonogenic properties and help define specific tumor microenvironments (TME). The interaction between CSCs and TME is thought to function as a dynamic support system that fosters the generation and maintenance of CSCs. Investigation of the interaction between CSCs and the TME is shedding light on the biologic mechanisms underlying the process of tumor malignancy, metastasis, and therapy resistance. We summarize recent advances in CSC biology and their environment, and discuss the challenges and future strategies for targeting this biology as a new therapeutic approach.
| Item Type: | Journal article |
|---|---|
| Form of publication: | Publisher's Version |
| Keywords: | Cancer stem cells; tumor microenvironments; therapeutic resistance; mechanism; strategy |
| Faculties: | Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| URN: | urn:nbn:de:bvb:19-epub-78871-3 |
| ISSN: | 2234-943X |
| Language: | English |
| Item ID: | 78871 |
| Date Deposited: | 15. Dec 2021 14:45 |
| Last Modified: | 26. Apr 2022 16:38 |
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