Lepko, Tjasa; Pusch, Melanie; Müller, Tamara; Schulte, Dorothea; Ehses, Janina; Kiebler, Michael; Hasler, Julia; Huttner, Hagen B.; Vandenbroucke, Roosmarijn E.; Vandendriessche, Charysse; Modic, Miha; Martin-Villalba, Ana; Zhao, Sheng; LLorens-Bobadilla, Enric; Schneider, Anja; Fischer, Andre; Breunig, Christopher T.; Stricker, Stefan H.; Götz, Magdalena; Ninkovic, Jovica (2019): Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. In: EMBO Journal, Vol. 38, No. 17, e100481 |
Abstract
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0261-4189 |
Language: | English |
ID Code: | 79586 |
Deposited On: | 15. Dec 2021 14:49 |
Last Modified: | 15. Dec 2021 14:49 |
- BASE
- Lepko, Tjasa
- Pusch, Melanie
- Müller, Tamara
- Schulte, Dorothea
- Ehses, Janina
- Kiebler, Michael
- Hasler, Julia
- Huttner, Hagen B.
- Vandenbroucke, Roosmarijn E.
- Vandendriessche, Charysse
- Modic, Miha
- Martin-Villalba, Ana
- Zhao, Sheng
- LLorens-Bobadilla, Enric
- Schneider, Anja
- Fischer, Andre
- Breunig, Christopher T.
- Stricker, Stefan H.
- Götz, Magdalena
- Ninkovic, Jovica
- Google Scholar
- Lepko, Tjasa
- Pusch, Melanie
- Müller, Tamara
- Schulte, Dorothea
- Ehses, Janina
- Kiebler, Michael
- Hasler, Julia
- Huttner, Hagen B.
- Vandenbroucke, Roosmarijn E.
- Vandendriessche, Charysse
- Modic, Miha
- Martin-Villalba, Ana
- Zhao, Sheng
- LLorens-Bobadilla, Enric
- Schneider, Anja
- Fischer, Andre
- Breunig, Christopher T.
- Stricker, Stefan H.
- Götz, Magdalena
- Ninkovic, Jovica