Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution

Alex, Jimi M.; Corvaglia, Valentina; Hu, Xiaobo; Engilberge, Sylvain; Huc, Ivan und Crowley, Peter B. (2019): Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution. In: Chemical Communications, Bd. 55, Nr. 74: S. 11087-11090

Abstract

Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a similar to 5 nm foldamer stack was surrounded by eight molecules of protein. NMR and CD experiments suggest interesting differences in the solution state recognition processes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1359-7345
• Sprache: Englisch