Lipids and polymers in pharmaceutical technology: Lifelong companions

Siepmann, Jürgen; Faham, Amina; Clas, Sophie-Dorothee; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnuerch, Andreas; Zhao, Hang; Lecommandoux, Sebastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J. und Leroux, Jean-Christophe (2019): Lipids and polymers in pharmaceutical technology: Lifelong companions. In: International Journal of Pharmaceutics, Bd. 558: S. 128-142

Abstract

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Annual Scientific Meeting of the Gattefosse Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0378-5173
• Sprache: Englisch