Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2)

Pfaff, Florian; Neubauer-Juric, Antonie; Krebs, Stefan; Hauser, Andreas; Singer, Stefanie; Blum, Helmut und Hoffmann, Bernd (2020): Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2). In: Archives of Virology, Bd. 166, Nr. 2: S. 639-643

Abstract

We present the complete genome sequence of bovine alphaherpesvirus 2 (BoHV-2), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus. BoHV-2 is the causative agent of bovine ulcerative mammillitis (bovine herpes mammillitis) and pseudo-lumpy skin disease. The genomic architecture of BoHV-2 is typical of most simplexvirus genomes and congruent with that of human alphaherpesvirus 1 (HHV-1). The genome comprises a total of 131,245 base pairs and has an overall G+C content of 64.9 mol%. A total of 75 open reading frames are predicted. The gene repertoire of BoHV-2 is analogous to that of HHV-1, although the coding region of US12 is missing. A phylogenetic analysis supported BoHV-2 as a member of the genus Simplexvirus.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Biochemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0304-8608
• Sprache: Englisch