Inhibition of Phytosterol Biosynthesis by Azasterols

Darnet, Sylvain; Martin, Laetitia B. B.; Mercier, Pierre; Bracher, Franz; Geoffroy, Philippe und Schaller, Hubert (2020): Inhibition of Phytosterol Biosynthesis by Azasterols. In: Molecules, Bd. 25, Nr. 5, 1111

Abstract

Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• Sprache: Englisch