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Song, Mengmeng; Scheifele, Maximilian; Barthel, Henryk; Eimeren, Thilo van; Beyer, Leonie; Marek, Ken; Eckenweber, Florian; Palleis, Carla; Kaiser, Lena; Finze, Anika; Kern, Maike; Nitschmann, Alexander; Biechele, Gloria; Katzdobler, Sabrina; Bischof, Gèrard; Hammes, Jochen; Jessen, Frank; Saur, Dorothee; Schroeter, Matthias L.; Rumpf, Jost-Julian; Rullmann, Michael; Schildan, Andreas; Patt, Marianne; Neumaier, Bernd; Stephens, Andrew W.; Rauchmann, Boris-Stephan; Perneczky, Robert; Levin, Johannes; Classen, Joseph; Höglinger, Günter U.; Bartenstein, Peter; Boening, Guido; Ziegler, Sibylle; Villemagne, Victor; Drzezga, Alexander; Seibyl, John; Sabri, Osama; Brendel, Matthias ORCID: 0000-0002-9247-2843 (2021): Feasibility of short imaging protocols for 18FPI-2620 tau-PET in progressive supranuclear palsy. In: European journal of nuclear medicine and molecular imaging, Vol. 48, No. 12: pp. 3872-3885
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Abstract

PURPOSE Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer 18FPI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for 18FPI-2620 tau-PET imaging of PSP. METHODS Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. 18FPI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20~min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60~min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier). RESULTS 0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86{\%}. CONCLUSION Truncated and static imaging windows can be used for 18FPI-2620 PET imaging of PSP. 0-40~min dynamic scanning offers the best balance between accuracy and economic scanning.