Characterization techniques for studying the properties of nanocarriers for systemic delivery

Merkel, Olivia M. und Mehta, Aditi (20. Oktober 2020): Characterization techniques for studying the properties of nanocarriers for systemic delivery. In: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Bd. 13. Cham: Springer. S. 57-86

Abstract

Nanocarriers have attracted a huge interest in the last decade as efficient drug delivery systems and diagnostic tools. They enable effective, targeted, controlled delivery of therapeutic molecules while lowering the side effects caused during the treatment. The physicochemical properties of nanoparticles determine their in vivo pharmacokinetics, biodistribution and tolerability. The most analyzed among these physicochemical properties are shape, size, surface charge and porosity and several techniques have been used to characterize these specific properties. These different techniques assess the particles under varying conditions, such as physical state, solvents etc. and as such probe, in addition to the particles themselves, artifacts due to sample preparation or environment during measurement. Here, we discuss the different methods to precisely evaluate these properties, including their advantages or disadvantages. In several cases, there are physical properties that can be evaluated by more than one technique. Different strengths and limitations of each technique complicate the choice of the most suitable method, while often a combinatorial characterization approach is needed.

• Dokumententyp: Buchbeitrag
• EU Funded Grant Agreement Number: 637830
• EU-Projekte: Horizon 2020 > ERC Grants > ERC Starting Grant > ERC Grant 637830: Novel asthma therapy - Biocompatible nanoparticles for T cell targeted siRNA delivery as novel asthma therapy
• Publikationsform: Submitted Version
• Keywords: nanoparticle characterization, nanoparticles, porosity, shape, size, surface charge
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
• ISBN: 978-3-030-54489-8
• Ort: Cham
• Sprache: Englisch

Literaturliste

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