ORCID: https://orcid.org/0000-0002-9450-7771; Delerue, Thomas; Schöttker, Ben; Holleczek, Bernd; Grill, Eva
ORCID: https://orcid.org/0000-0002-0273-7984; Peters, Annette
ORCID: https://orcid.org/0000-0001-6645-0985; Waldenberger, Melanie
ORCID: https://orcid.org/0000-0003-0583-5093; Thorand, Barbara
ORCID: https://orcid.org/0000-0002-8416-6440 and Brenner, Hermann
ORCID: https://orcid.org/0000-0002-6129-1572
(2022):
Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
In: Nature Communications, Vol. 13, 5269
[PDF, 745kB]
Abstract
DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up.
Item Type: | Journal article |
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Faculties: | Medicine > Institute for Medical Information Processing, Biometry and Epidemiology Medicine > Institute for Medical Information Processing, Biometry and Epidemiology > Epidemiology of Vertigo and Dizziness |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-93674-2 |
ISSN: | 2041-1723 |
Language: | English |
Item ID: | 93674 |
Date Deposited: | 23. Nov 2022, 08:37 |
Last Modified: | 11. Jan 2023, 12:22 |