Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults

Li, Xiangwei ; Delerue, Thomas; Schöttker, Ben; Holleczek, Bernd; Grill, Eva ; Peters, Annette ; Waldenberger, Melanie ; Thorand, Barbara und Brenner, Hermann (2022): Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults. In: Nature Communications, Bd. 13, 5269

Abstract

DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie ; Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie > Epidemiologie für Schwindelerkrankungen
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2041-1723
• Sprache: Englisch